| 摘要 |
<p>A compound of the general formula:
<Chemistry id="chema01" num="0001"><Image id="ia01" he="23" wi="135" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" inline="no" /></Chemistry>wherein m is an integer of I to 7,
<UnorderedLists id="ula01" listStyle="none"><ListItem>n is 0 or an integer of I to 5,</ListItem><ListItem>R' is the phenyl, a substituted phenyl, the phenoxy, a substituted phenoxy or a saturated or unsaturated straight alkyl having 5 to 18 carbon atoms, <!-- EPO <DP n="2"> -->R<Sup>2</Sup> is hydrogen atom,</ListItem><ListItem>R<Sup>3</Sup> is hydrogen atom, a branched or unbranched alkyl having 3 to 5 carbon atoms, the phenyl, hydroxyphenyl, benzyloxyphenyl, an alkylthio having I to 3 carbon atoms in its alkyl moiety, amino, carboxyl, hydroxy, benzyloxy, indolyl or imidazolyl, or R<Sup>2</Sup> and R<Sup>3</Sup> together form a single bond between the carbon atom and the nitrogen atom, and a pharmaceutical composition containing said compound are provided. The compound is effective in curing amnesia because of its anti-prolyl endopeptidase activity and may be used in the preparation of an anti-prolyl endopeptidase medicament, and. in the preparation of a medicament for treating brain malfunction.</ListItem></UnorderedLists></p> |
