| 摘要 |
Various effects of photo-aging (sundamage) of the skin including impairment of the differentiation of epidermal epithelial cells, loss of collegan fibers, abnormal changes in the elastic fibers, and deterioration of small blood vessels in the dermis of the skin are retarded by applying topically to the epidermis of the skin in a program of maintenance therapy effective amounts of vitamin A acid (tretinoin) such that epithelial growths are substantially reduced and prevented, and the skin substantially regains and maintains its firmness, turgor and elasticity. Moreover, with persistent treatment dermal blood cells and vessels increase and the epidermis and dermis thicken, resulting in improved ability of the skin to sense, resist and recover from irritation or injury. Further, hyperpigmentation, lines and wrinkles due to aging are reduced and prevented. The treatment is particularly useful for human facial skin and preferably applied in an emollient vehicle in sub-irritating doses.
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