INDOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR PREPARING THEM

摘要

This invention relates to compounds of general formula I < IMG > (I) ¢wherein A represents a -CH2-CH2-, -CH=CH-, -?H-CO-or -?H2-CO- group and B represents a methylene, carbonyl or thiocarbonyl group, or A represents a -CO-CO- or < IMG > group and B represents a methylene group; E represents a straight-chained alkylene group containing 2 to 4 carbon atoms optionally substituted by an alkyl group containing 1 to 3 carbon atoms, or represents a 2-hydroxy-n-propylene, 2-hydroxy-n-butylene or 3-hydroxy-n-butylene group; G represents a straight-chained alkylene group containing 1 to 5 carbon atoms optionally substituted by an alkyl group containing 1 to 3 carbon atoms; R1 represents a hydrogen, chlorine or bromine atom or a trifluoromethyl, nitro, amino, alkylamino, dialkylamino, alkyl, hydroxy, alkoxy or phenylalkoxy group (in which each alkyl moiety may contain 1 to 3 carbon atoms) and R2 represents a hydrogen, chlorine or bromine atom or a hydroxy, alkoxy, phenylalkoxy or alkyl group (in which each alkyl moiety may contain 1 to 3 carbon atoms); or R1 and R2 together represent an alkylenedioxy group containing 1 or 2 carbon atoms; R3 represents a hydrogen, chlorine or bromine atom or an alkyl group containing 1 to 4 carbon atoms; R4 represents a hydrogen atom or an alkyl or phenylalkyl group (in which each alkyl moiety may contain 1 to 3 carbon atoms); R5 represents a hydrogen, fluorine, chlorine or bromine atom or an alkyl, hydroxy, alkoxy or phenylalkoxy group (in which each alkyl moiety may contain 1 to 3 carbon atoms); R6 represents a hydrogen atom or an alkoxy group containing 1 to 3 carbon atoms; and R7 represents a hydrogen atom, an alkenyl group containing 3 to 5 carbon atoms or an alkyl or phenylalkyl group (in which each alkyl moiety may contain 1 to 3 carbon atoms)! and acid addition salts thereof which have interesting pharmacological properties, particularly a heart rate-lowering activity. The new compounds may be obtained using methods known per se.