发明名称 |
Temperature sensitive reassortant viruses and a vaccine against equine influenza |
摘要 |
This invention relates to a method and resulting temperature-sensitive (ts) reassortant virus produced by modifying wild-type equine influenza viruses by utilizing mutagenized human influenza viruses possessing ts lesions and shut off temperatures in the area of 37 DEG -39 DEG C., preferably 37 DEG -38 DEG C. When utilized as a vaccine for equines, these temperature-sensitive recombinant viruses have the facility to develop only mild symptoms while producing protection against infectious equine influenzal disease.
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申请公布号 |
US4683137(A) |
申请公布日期 |
1987.07.28 |
申请号 |
US19840634510 |
申请日期 |
1984.07.26 |
申请人 |
CORNELL RESEARCH FOUNDATION, INC. |
发明人 |
COGGINS, LEROY;MURPHY, BRIAN R.;HOLMES, DOROTHY F.;ANGUISH, LYNNE J.;GILLESPIE, JAMES H. |
分类号 |
A61K39/145;C12N7/00;(IPC1-7):A61K39/12 |
主分类号 |
A61K39/145 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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