| 摘要 |
A multi-stage, e.g. two stage, continuous culture process, in which host cells transformed with DNA coding for a product are grown in an initial stage in which product formation is uninduced and a subsequent stage in which product formation is induced. Culturing is continued for extended periods of time whilst maintaining satisfactory and sustained levels of product formation by maintaining the specific growth rate of cells in the induced stage at or near the maximum specific growth rate of the cells under the given culture conditions. |
