| 摘要 |
Carbapenems and 1-methylcarbapenems having the formula: <IMAGE> wherein R1 and R2 are independently H, CH3, CH3CH2-, (CH3)2CH-, HOCH2, CH3CH(OH)-, (CH3)2C(OH)-, FCH2-, F2CH, F3C-, CH3CH(F)-, CH3CF2-, or (CH3)2 C(F)-; R3 is H- or CH3; L is a bridging group comprising substituted or unsubstituted C1-C4 straight, C2-C6 branched or C3-C7 cycloalkyl groups wherein the substituents are selected from C1-C6 alkyl, O-C1-C6 alkyl, S-C1-C6 alkyl, CF3, N(C1-C6 alkyl)2; N+ is a quaternary, monocyclic or bicyclic substituted or unsubstituted, heteroaryl group containing (a) when monocyclic, up to 3 heteroatoms and up to 6 total ring atoms, or (b) when bicyclic, up to 5 heteroatoms and 9-10 ring atoms, which is optionally substituted with one or more groups; their preparation and antibiotic use are disclosed.
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