| 摘要 |
NEW MATERIAL:A pyridonebenzoxazinecarboxylic acid derivative expressed by formula I [Y is formula II (R1 and R2 are H or lower alkyl; n is 2 or 3 m is 1 or 2, provided that at least one of R2 is lower alkyl when n represents 2) or formula III (R3, R4 and R5 are H or lower alkyl, n' is 0 or 1)] and a salt thereof. EXAMPLE:10-(3-Dimethylamino-1-pyrrolidinyl)-9-fluoro-3-fluoromethyl-7- oxo-2,3-di hydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid. USE:Useful as an antimicrobial agent capable of exhibiting powerful activity against Gram-positive bacteria, e.g. Staphylococcus aureus, enterococcus, etc., and Gram-negative bacteria, e.g. Escherichia coli, shigella, etc. PREPARATION:For example, a compound expressed by formula IV is reacted with a diamine compound expressed by the formula YH to afford the aimed compound expressed by formula I. |
