发明名称 |
Polyacrolein microspheres |
摘要 |
Microspheres of acrolein homopolymers and copolymer with hydrophillic comonomers such as methacrylic acid and/or hydroxyethylmethacrylate are prepared by cobalt gamma irradiation of dilute aqueous solutions of the monomers in presence of suspending agents, especially alkyl sulfates such as sodium dodecyl sulfate. Amine or hydroxyl modification is achieved by forming adducts with diamines or alkanol amines. Carboxyl modification is effected by oxidation with peroxides. Pharmaceuticals or other aldehyde reactive materials can be coupled to the microspheres. The microspheres directly form antibody adducts without agglomeration.
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申请公布号 |
US4678814(A) |
申请公布日期 |
1987.07.07 |
申请号 |
US19850750028 |
申请日期 |
1985.07.01 |
申请人 |
CALIFORNIA INSTITUTE OF TECHNOLOGY |
发明人 |
REMBAUM, ALAN |
分类号 |
A61K9/51;A61K47/48;C08F2/54;C08F16/34;G01N33/543;(IPC1-7):C08F2/54 |
主分类号 |
A61K9/51 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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