发明名称 |
TISSUE PLASMINOGEN ACTIVATOR (TPA) ANALOGS |
摘要 |
Human tissue plasminogen activator (TPA) analogs. The analogs are TPA-like molecules that have had the native domain regions either rearranged, deleted, added or a combination thereof. The analogs are the product of the expression of recombinant DNA also described herein. Additionally, the present invention describes replication and expression plasmids containing the TPA-coding DNA sequences described above and suitable host microorganisms that are capable of expressing the TPA analogs after becoming transformed with an appropriate plasmid. |
申请公布号 |
WO8703906(A1) |
申请公布日期 |
1987.07.02 |
申请号 |
WO1986US02684 |
申请日期 |
1986.12.12 |
申请人 |
THE UPJOHN COMPANY |
发明人 |
MAROTTI, KEITH, R.;REHBERG, EDWARD, F.;THERIAULT, NICOLE, Y. |
分类号 |
C12N9/64;A61K38/00;C07K;C12N1/16;C12N1/20;C12N5/00;C12N9/72;C12N15/00;C12N15/09;C12N15/58;(IPC1-7):C12N15/00 |
主分类号 |
C12N9/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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