| 摘要 |
1. Claims for the contracting states : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE Modified GPIR (Ribosome-inhibiting glycoprotein), retaining the ribosome-inhibiting activity of native GPIR and of which the in-vivo action period is prolonged with respect to that of the GPIR, characterized in that it is obtained by treatment of the GPIR with jointly an aqueous solution of a periodate and an aqueous solution of a cyanoborohydride, said treatment being carried out in aqueous solution of pH 5 to 7, at a temperature of 0 to 15 degrees C in the dark and for a period of 4 to 24 hours. 1. Claims for the contracting states : AT, ES, GR Process for obtaining a GPIR (Ribosome-inhibiting glycoprotein) retaining the ribosome-inhibiting activity of native GPIR and of which the in-vivo action period is prolonged with respect to that of the GPIR, characterized in that it is obtained by treatment of the GPIR with jointly an aqueous solution of a periodate and an aqueous solution of a cyanoborohydride, said treatment being carried out in aqueous solution of pH 5 to 7, at a temperature of 0 to 15 degrees C in the dark and for a period of 4 to 24 hours. |
