| 摘要 |
NEW MATERIAL:An imidazole derivative expressed by formula I (R<1> is H, hydroxy lower alklyl, hydroxyimino lower alkyl, lower alkoxyimino lower alkyl, formyl, carboxy, etc.; R<2> is H, lower alkyl or lower alkanoyl; R<3> is hydroxyl group, mercapto, lower alkoxy, lower alkylthio, lower alkanoyloxy, etc., provided that R<3> is lower alkanoyloxy or lower alkanoylthio, etc., when R<1> is H) or a salt thereof. EXAMPLE:4-(3,5-Di-tert-butyl-4-hydroxyphenyl)-5-formyl-2-methylthioimi dazole. USE:Useful as an anti-inflammatory agent, antipyretic agent, analgesic agent, antirehumatic agent, antiarthritic agent or antiosteoporotic agent. PREPARATION:For example, a compound expressed by formula II is reacted with methylformamide in the presence of thionyl chloride, etc., to afford the aimed compound expressed by formula I (R<1> is formyl).
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