摘要 |
Cytotoxyc medicaments which contain the compounds of formula (I) or a physiologically compatible salt thereof, whereby in formula (I) R is a saturated or unsaturated carbon residue with 12 to 14 C atoms, which can also be halogen-substituted, X is an oxygen atom, NH or NR2 and Y is an oxygen atom or NH, R1 is a C1-C8-alkyl group or wherein R1 represents a C2-C8 alkyl group which is unsaturated and/or is substituted by halogen, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, tri-C1-C6-alkylamino, hydroxy, carboxy, C3-C8-cycloalkyl or phenyl, and wherein R1, in addition, may also be 2-tert.-butyloxycarbonylaminoethyl, 2-tert.-butyloxycarbonylethyl, 2,3-isopropylidenedioxy-propyl-(1), 2,3-dibenzyloxy-propyl-(1), 1,3-dibenzyloxy-propyl-(2) or N-C1-C6-alkylamino-C2-C6-alkyl, if X is an oxygen atom, and wherein R1, in addition, may also be 2,3-dihydroxypropyl-(1), if X is the NH-group, and R2 is a 2,3-dihydroxylpropyl-(1)-group, a C1-C8 alkyl group or a C2-C8 alkyl group which is unsaturated and/or is substituted with halogen, amino, C1-C6-alkylamino, di-C1-C6-alkylamino, tri-C1-C6-alkylamino, hydroxy, carboxy, C3-C8-cycloalkyl or phenyl, compounds of formula (I) and processes for their production. |