摘要 |
<p>A pharmaceutical composition useful for treating bacterial infections in mammals which comprises (A) a B-lactam antibiotic and (B) a penicillin derivative represented by the following formula wherein R1 and R2 are each the same or different and represent hydrogen, Cl-18 alkyl, mononitro-substituted benzyl or group for forming a pharmaceutically acceptable salt and R3 is selected from the group consisting of hydrogen, Cl-6 alkyl, C2-7 alkoxymethyl, C3-8 alkylcarbonyloxymethyl, C4-9 alkylcarbonyloxyethyl, (C5-7 cycloalkyl)carbonyloxymethyl, C9-14 benzylcarbonyloxyalkyl, C3-8 alkoxycarbonylmethyl, C4-9 alkoxycarbonylethyl, phthalidyl, crotonolacton-4-yl, Y-butyrolacton 4-yl, halogenated Cl-6 alkyl substituted with 1 to 3 halogen atoms, C1-6 alkoxy- or nitro-substituted or unsubstituted benzyl, benzhydryl, tetrahydropyranyl, dimethylaminoethyl, dimethylchlorosilyl, trichlorosilyl, (5-substituted C1-6 alkyl or phenyl or unsubstituted2-oxo-1,3-dioxoden-4-yl)methyl, C8-13 benzoyloxyalkyl and group for forming a pharmaceutically acceptable salt.</p> |