| 摘要 |
PURPOSE:To obtain the titled compound useful as an anti-inflammatory agent in high yield without forming isomers, by halogenating 2-(p-methylphenyl) propionic acid or an ester thereof as a raw material in the presence of a radical generating agent. CONSTITUTION:2-(p-Methylphenyl)propionic acid or an ester expressed by formula I (R is H or lower alkyl) as a raw material is reacted with a halogenating agent, e.g. chlorine, bromine, N-bromosuccinimide, etc., in the presence of a radical generating agent (particularly preferably azobisisobutyronitrile or light and preferably in an amount of about 0.5-2.0wt% based on the raw material or while continuously irradiating for the light) to afford the aimed 2-(p- halomethylphenyl)propionic acid or ester thereof expressed by formula II (R is same as defined above; X is halogen atom, e.g. Cl, Br I, etc.).
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