| 摘要 |
NEW MATERIAL:An inclusion compound of prednisolone with heptakis (2,6-di-O- methyl)-beta-cyclodextrin. External appearance; white crystalline powder. solubility; greatly soluble in water. USE:Water-solubility of an adrenal cortex steroid prednisolone useful as an anti- inflammatory agent is enhanced and absorbability thereof by the oral and percutaneous administration is improved. Since the dose of prednisolone can be reduced, side reaction can be suppressed and the use thereof is economically advantageous. PREPARATION:Prednisolone and keptakis(2,6-di-O-methyl)-beta-cyclodextrin are mixed together, for example, at 1:1-1:5 molar ratio of the former to the latter and purified water is added to knead the mixture. Thus obtained pasty mixture is dried such as under reduced pressure to obtain the aimed powdery compound.
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