A process for the preparation of sodium amoxycillin.

摘要

Sodium amoxycillin, of use for example by parenteral administration, is prepared by:
(a) suspending amoxycillin trihydrate in a mixture consisting of an aprotic organic solvent and a lower alcohol;(b) solubilising the amoxycillin trihydrate by the addition of a low molecular weight amine of the group of cyclic or heterocyclic aliphatics;(c) adding to such solution the sodium salt of diethyloxalacetic acid or the sodium salt of 2-ethylhexanoic acid, agitating the reaction mixture at a temperature of from -10°C to ambient temperature and finally isolating the sodium amoxycillin by filtration after its precipitation in the reaction medium by the addition of an aprotic organic solvent.