| 发明名称 |
CYCLOALKYL-SUBSTITUTED-4-AMINOPHENYL DERIVATIVES AND PROCESS FOR THEIR PREPARATION |
| 摘要 |
Cycloalkyl substituted 4-aminophenyl derivatives of formula (I) …<CHEM>… wherein… R is C1-C4 alkyl:… n is an integer of 1 to 5; and either … … (a) A is @C=O and B is -O-, -NH- or -CH2-; or … (b) A is -CH2- and B is -O-, -NH-, -CH2- or @C=O; or … (c) A is -O- and B is @C=O or -CH2-; or … (d) A is -NH- and B is @C=O or -CH2-; … and their pharmaceutically acceptable salts show aromatase inhibiting activity and can be useful, e.g. in treating hormone-dependent tumors and prostatic hypertrophy or hyperplasia. |
| 申请公布号 |
ZA8606766(B) |
申请公布日期 |
1987.04.29 |
| 申请号 |
ZA19860006766 |
申请日期 |
1986.09.05 |
| 申请人 |
FARMITALIA CARLO ERBA S.P.A. |
发明人 |
PAOLO LOMBARDI;ANGELO CRUGNOLA;ENRICO DI SALLE |
| 分类号 |
C12N9/99;A61K31/135;A61K31/165;A61K31/215;A61P13/02;A61P15/00;A61P35/00;A61P43/00;C07C67/00;C07C201/00;C07C205/06;C07C205/42;C07C205/56;C07C205/57;C07C209/00;C07C209/36;C07C209/50;C07C211/45;C07C213/00;C07C217/76;C07C227/00;C07C227/04;C07C227/18;C07C229/42;C07C231/00;C07C231/02;C07C231/12;C07C233/12;C07C233/62;C07C237/20 |
主分类号 |
C12N9/99 |
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