发明名称 Lipoxygenase inhibiting 1-arylalkyl-, 1-arylthio-, and 1-aryloxypyrazole-4,5-diones
摘要 Combating diseases of the respiratory tract, inflammations, rheumatism, thromboembolic diseases, ischaemias and infarcts, cardiac arrhythmias and arteriosclerosis with pyrazolediones of the formula <IMAGE> wherein R represents an aryl or heteroaryl radical which has 6 to 12 C atoms and optionally contains 1 to 3 identical or different substituents from the group comprising halogen, trifluoromethyl, alkyl, alkenyl, alkoxy, alkylamino, cyano, trifluoromethoxy, nitro, hydroxyl, SOn-alkyl (n=0 to 2) or SOn-trifluoromethyl ) n=0 to 2), alkyl, alkenyl and alkoxy each having up to 4 C atoms, R1 represents hydrogen or a hydrocarbon radical which has 1 to 18 C atoms and optionally contains a hydroxyl, ether, ester or carboxyl group and optionally contains 1 to 3 halogen atoms, and X represents one of the groups -CH2-CH2-CH2-, -O-CH2-CH2-, -S-CH2-CH2-, -CH2-CH2-, -CH2- or <IMAGE> the oxygen or sulphur atom being bonded to the radical R.
申请公布号 US4659732(A) 申请公布日期 1987.04.21
申请号 US19850769928 申请日期 1985.08.27
申请人 BAYER AKTIENGESELLSCHAFT 发明人 STEGELMEIER, HARTMUT;FIEDLER, VOLKER;MARDIN, MITHAT;MAYER, DIETER;PERZBORN, ELISABETH;SEUTER, FRIEDEL
分类号 C12N9/99;A61K31/415;A61P7/02;A61P9/06;A61P9/08;A61P9/10;A61P11/00;A61P29/00;A61P43/00;C07D231/28;(IPC1-7):A61K31/415 主分类号 C12N9/99
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