摘要 |
Cyclic-keto-acids of the general formula: <CHEM> wherein R is hydrogen or a monovalent alkyl radical which can be either straight chain or branched having from 1 to 20 carbon atoms and X = 1, 3, 4 or 5, are prepared by reacting a functionalized 1-bromoalkane of the formula: R-@H(CHR)xCH2Br wherein R and X are as defined above and Y is a leaving group, preferably the halogens, in a liquid solvent medium with carbon monoxide at elevated temperature and pressure in the presence of a catalytic amount of a metal carbonyl compound and an alkali or an alkaline earth metal inorganic base. |