Antimicrobial substituted 2-amino-5-nitroth

摘要

Antimicrobial substd. 2-amino-5-nitrothiazole. 2-(4:5:-Trimethyl-1:3-oxazolidinylidene-(2))-amino-5-nitrothiaz- ole, and its acid addition salts, is particularly effective against Trichomonas. It may be prepd. (a) by reaction between a 2-methylamino-5-nitrothiazole and a substd. 2-amino-3-methylbutanol (3), the reaction taking place, if necessary, in the presence of a heavy metal oxide which forms complexes of low solubility with the mercaptan, (b) by reaction at low temp. or 100 degrees C between a mercapto-4:5:5-trimethyl-DELTA 2-oxazoline and 2-aminonitrothiazole, and (c) by nitrating 2-4:5:5-trimethyl-2-oxazolidinylidene)-amino-thi azole with a mixture of concentrated H2SO4 and HNO3 at between 0 degree C and ambient temp.