| 摘要 |
Compounds of formula (i) and pharmaceutically acceptable salts thereof: <IMAGE> (I) wherein: m and n are independently 1 or 2 and p is 0, 1 or 2 such that m+n+p>/=3; R1 and R2 are independently hydrogen, C1-6 alkyl, phenyl or phenyl-C1-6 alkyl, which phenyl moieties may be substituted by C1-6 alkyl, C1-6 alkoxy or halogen; Ar is a group of formula (a): <IMAGE> (a) wherein either R3 is hydrogen or C1-7 alkanoyl; and X is chloro, bromo, methylthio or nitro; having gastric motility enhancing activity, anti-emetic activity and/or 5-HT antagonist activity, a process for their preparation, and their use as pharmaceuticals. |
