3-HYDROXYALKANOIC ACID DERIVATIVES

摘要

NEW MATERIAL:A compound shown by formula I [R<1> is hydroxyalkyl which may be protected; R<2> is alkyl; R<3> is R<1>, H or alkyltrisubstituted silyl; R<4> is (substituted)OH or (substituted)amino or a salt thereof. EXAMPLE:5-Benzyloxy-2-[1-tertiary butyldimethylsilyloxyethyl)-3-hydroxy-N-me thoxy-4-methylpentanamide. USE:An intermediate for producing an 1-alkylcarbapenem compound having strong antibacterial action on many pathogenic bacteria. PREPARATION:For example, a compound shown by formula II is reacted with a compound shown by formula III (R<4> is substituted OH; R<5> is OH-protecting group) to give a corresponding compound shown by formula I.