AZIRIDINE PHENETHANOLAMINE DERIVATIVES

摘要

Aziridine and phenethanolamine derivatives of formulae I and II-l I-l II-l wherein R1 and R2 signify hydrogen or lower-alkyl; Z1 signifies phenyl or a phenyl group substituted in a defined manner, Z2 and Z21 signify a phenyl or thienyl group substituted in a defined manner and n signifies 1-4 have catabolic activity and can be used for the treatment of obesity and/or of sugar illnesses. The compounds of formula I are obtained by dehydrating .beta.-aminoalcohols (e.g. those of formula II-1) which, in turn, can be prepared by adding amines to epoxides or by reducing corresponding iminoketones, iminoalcohols .alpha.-keto-.beta.-hydroxyamines or .beta.-ketoamines.