摘要 |
A method for the treatment and/or prophylaxis of cerebrovascular disorders and/or disorders associated with cerebral senility in mammals, such as humans, which comprises administering to the mammal in need of such treatment and/or prophylaxis an effective and/or prophylactic amount of a compound of formula (I): <IMAGE> (I) wherein (i) R1 is a group -X-CO-CH3 where X is a hydrocarbon radical having up to 4 carbon atoms which may be substituted by a methyl group, R2 and R3, which may be the same or different, each represents a straight-chain or branched-chain alkyl radical of 2 to 6 carbon atoms, or a cyclohexyl, alkoxyalkyl or hydroxyalkyl radical, and Y and Z each represent oxygen; (ii) R1 is a group -CH2(OR4)(OR5)CH3 wherein R4 is an alkyl radical of 1 to 4 carbon atoms and R5 is an alkyl radical of 1 to 4 carbon atoms or R4 is linked to R5 so that the OR4 and OR5 moieties and the carbon atoms to which they are attached form a 1,3-dioxacylohexa-2,2-diyl,1,3-dioxacyclopenta-2, 2-diyl or 1,3-dioxacyclohepta-2,2-diyl diradical, R2 and R3 are the same or different and are each an alkyl radical of 1 to 4 carbon atoms, and Y and Z each represent oxygen; (iii) R1 is a group -CH2COCH3, R2 is an alkyl radical of 1 to 6 carbon atoms, R3 is an alkyl radical of 1 to 6 carbon atoms, Z is sulphur and Y is oxygen or sulphur; (iv) R1 is a group -(CH2)nCOCH3 where n is 1 or 2, one of R2 and R3 is an alkyl radical of 1 to 6 carbon atoms and the other is an alkyl radical of 2 to 6 carbon atoms, Z is oxygen and Y is sulphur; or (v) R1 is a group -CH2COCH3, R2 is an alkyl radical of 1 to 4 carbon atoms, R3 is a group CH3CO(CH2)4-, and Y and Z each represent oxygen. |