| 摘要 |
Compounds of the formula: …<CHEM>… (wherein R<3> represents -CONRR<9>, -COOR or -COC(R<1><0>) (R<1><1>)R; R<4> represents -NR<1><2>R<1><3> or -OR<1><2>; R<5>, R<6>, R<7> and R<8> each independently represent hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, optionally substituted aryl, (optionally substituted aryl)alkyl, fluoroalkyl, haloalkenyl, alkoxyalkyl, hydroxyalkyl, halogen, alkoxy, alkenyloxy, hydroxy, nitro, cyano or optionally substituted amino; R and R<9> each independently represent hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, optionally substituted aryl, (optionally substituted aryl) alkyl, 4,5-dihydro-2-thiazolyl, alkoxyalkyl, hydroxyalkyl, fluoroalkyl or haloalkenyl, or R and R<9> together form an alkylene group optionally interrupted by an oxygen atom or an alkenylene group; R<1><0> and R<1><1> each independently represent hydrogen or alkyl; R<1><2> and R<1><3> each independently represent hydrogen, alkyl, acyl or cycloalkylalkyl) and the pharmaceutically acceptable salts and 1- or 2-position N-oxides thereof possess anxioltyic activity. |
