3-O-acyl-4''-deoxydesmycosin derivatives

摘要

Novel 3-O-acyl-4''-deoxydesmycosin derivatives of the formula <IMAGE> wherein R1 is lower alkyl, phenyl, substituted phenyl, phenyl-lower alkyl or substituted phenyl-lower alkyl, R2 is hydrogen or -CHO and R3 is hydrogen or hydroxyl, or a non-toxic salt thereof, can be produced by acylating the hydroxyl group at position-3 of the corresponding intermediate while protecting the hydroxyl at position-2' or positions-2' and -4' with acetyl, and then removing the protective group or groups. These derivatives have antibiotic utility against Gram positive and Gram negative bacteria.