Hydroxamic acid based collagenase inhibitors.

摘要

This invention relates to a novel class of hydroxamic acid based collagenase inhibitor derivatives of the formula

wherein R<1> is C1-C6 alkyl; R<2> is C1-C6 alkyl, benzyl, hydroxybenzyl, benzyloxybenzyl, (C1-C6 alkoxy)benzyl, or benzyloxy(C1-C6 alkyl); a is a chiral center with optional R or S stereochemistry; A is a
-(@HR<3>-@HR<4>)-

group or a -(CR<3> = CR<4>)- group wherein b and c are chiral centers with optional R or S stereochemistry; R<3> is hydrogen, C1-C6 alkyl, phenyl, or phenyl (C1-C6 alkyl); and R<4> is hydrogen or C1-C6 alkyl, phenyl (C1-C6 alkyl), cycloalkyl, or cycloalkyl (C1-C6 alkyl). The invention further relates to pharmaceutical compositions containing such compounds for the treatment of collagenase induced diseases.