摘要 |
Macrolides having the formula: <CHEM> in which R1, R2, R3 and the 22,23-linkage have the following values: A: R1 = H, R2 = OH, R3 = CH3, 22,23-single bond B: R1 = H, R2 = OH, R3 = CH3, 22,23-double bond C: R1 = OH, R2 = H, R3 = H, 22,23-double bond are isolated from the fermentation broth, using avermectin Bla, avermectin Blb or 22,23-dihydro avermectin Bla as a substrate, of Nocardia autotrophica ATCC 35203. The compounds are highly potent antiparasitic, insecticidal, and anthelmintic agents and can be made into compositions for such uses. |