METHOD OF TREATING HEPATITIS

摘要

Method of treating an animal infected by hepatitis B virus comprising administering to such infected animal an amount of a rifamycin derivative selected from a group consisting of (a) 3-amino-4-deoxo-4-imino-rifamycin S, (b) 3-amino-4-deoxo-4-¨AD(4-aminophenyl)sulfonyl¨BDamino-rifamycin SV, (c) 4-O-(n-butylsulfonyl)-3-¨AD(1-piperidinylimino)methyl¨BD-rifamycin SV, (d) 4-O-(n-butysulfonyl)-3-¨AD(4-morpholinylimino)methyl¨BD-rifamycin SV, (e) 3-¨AD(dimethylhydrazono)methyl¨BD-4-O-¨AD(3-phenylpropyl)sulfonyl¨BD-rifamycin SV, and (f) 4-deoxo-N,3-ethylidenimino-4-(methylsulfonyl)amino-rifamycin SV, said amount being effective to alleviate the effects of said hepatitis B virus. Also disclosed is a method of inhibiting the viral polymerase of hepatitis B virus by subjecting said polymerase to an amount of one of the rifamycin derivatives (a)-(f) above, said amount being effective to prevent the synthesis of hepatitis B virus by said viral polymerase. Compounds (b)-(f) described above are novel compounds.