| 摘要 |
N-acyl-phenylalanine derivs. (I) [R1,R2=H, alkyl, alkoxy, halo, OH, or R1R2=methylenedioxy; R3=Me, Ph were prepd. from 4-benzylidene-5- oxazolone derivs. by hydrolysis and reduction. Thus, 2-methyl-4- benzylidene-5-oxazolone was cleaved by NaOH to yield PhCH:C(NHCOMe) CO2Na, which was hydrogenated over Pt to give PhCH2CH(NHCOMe)CO2H. (I) are useful for prodn. of L-phenylalanine, which is an intermediate in the mfr. of the sweetneraspartame.
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