| 摘要 |
<p>1-{2-[5-dimethylaminomethyl-2-(furylmethylthio)-ethyl]}-amino-1-methyl amino-2 - nitroethylene of the formula (I> <IMAGE> and its hydrochloride, are prepared by reacting an 1-{2-[5-dimethylaminomethyl-2-(furylmethylthio)-ethyl]}-amino-1-(subst ituted thio)-2- nitroethylene of the formula (VI), <IMAGE> wherein R represents an optionally substituted C1-4 alkyl group or an oxoalkyl, aryl, aralkyl, or oxoaralkyl group, with an agent capable of splitting off a mercapten, in an organic solvent, optionally in the presence of an acid-binding agent, then reacting the in situ prepared 1-{2-[5-dimethylaminomethyl-2-(furylmethylthio)-ethyl]}-3-nitroketenei mine of the formula (VII> <IMAGE> with methylamine and finally, if desired, separating the obtained base of formula (I), purifying it and/or, if desired, transforming it to its hydrochloric salt.</p> |
