| 摘要 |
NEW MATERIAL:A compound expressed by formula I(R1 to R3 are methoxyl, OH or H). EXAMPLE:(Z)-3-Butylidene-6,7-dimethoxyphthalide. USE:A prostaglandin F2alpha inhibitor. PREPARATION:Commercially available 2,3-dimethoxybenzoic acid, etc., are chloromethylated, etc., to provide a compound expressed by formula II (R8 is methoxymethoxyl, methoxyl or H), which is then converted into the objective compound expressed by formula I. Compounds expressed by formula III (R4 and R5 are methoxyl or OH) and formula IV (R5 and R6 are methoxyl or OH) are cited as the phthalide derivative obtained by the aforementioned method. |
