Granular anhydrous dicalcium phosphate compositions suitable for direct compression tableting.

摘要

A granular anhydrous dicalcium phosphate having a particle of a size sufficient for direct compression tablets and a surface area of greater than 5 meters²/gram can be direct compression tableted. This product can be prepared by dehydrating granules of dicalcium phosphate dihydrate of a particle size sufficient for direct compression tableting and sufficiently large to allow the dehydration of the granules without lumping and without fracturing a majority of the granules. The granules are heated at a temperature sufficient to form anhydrous dicalcium phosphate. The product is a granular anhydrous dicalcium phosphate exhibiting good compressibility, flowability and whiteness while being in an anhydrous state.