PENTAPEPTIDES WITH CELL GROWTH REGULATORY EFFECTS AND A PROCESS FOR THE PREPARATION THEREOF

摘要

PCT No. PCT/NO86/00041 Sec. 371 Date Feb. 18, 1987 Sec. 102(e) Date Feb. 18, 1987 PCT Filed Jun. 18, 1986 PCT Pub. No. WO87/00180 PCT Pub. Date Jan. 15, 1987.New pentapeptide of the formula I in which X1 and X2 are the same or different and are OH or NH2, Y is H or OH, X3 is CO or CH2, one of the groups Z1 and Z2 is H and the other is H or CH3, all the amino acid unit being in L-configuration, with the exception that the C-terminal amino acid unit is in D-configuration when Z2 is methyl, and the C-terminal carboxyl group may be reduced to -CH2-OH or be in amide form, and cation complexes and salts thereof. The pentapeptide may be prepared by subjecting a protected derivative thereof to deprotection. The pentapeptide has cell growth regulatory activity.