发明名称 |
METHOD OF PRODUCING 6-AMINO-7-OXY-4,5,6,7-TETRAHYDROIMIDAZO-(4,5,1-J-K)-(1)-BENZAZEPIN-2(1N)-ON DERIVATIVES OR ACID-ADDITIVE SALTS THEREOF |
摘要 |
Novel 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,l-j-k][1]-benzazepin- 2-(1H)-one derivatives of the formula <IMAGE> wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally substituted with a hydroxyl, aryl and aryloxy of 6 to 10 carbon atoms, cycloalkyl of 3 to 7 carbon atoms optionally interrupted with a heteroatom optionally substituted with alkyl of 1 to 4 carbon atoms and the wavy lines indicates that the 7-OH and 6-amino have the trans configuration and their non-toxic, pharmaceutically acceptable acid addition salts having remarkable anti-hypertensive and hypotensive activity and vasodilatatory activity and their preparation. |
申请公布号 |
SU1287753(A3) |
申请公布日期 |
1987.01.30 |
申请号 |
SU19833654552 |
申请日期 |
1983.10.11 |
申请人 |
ROUSSEL UCLAF |
发明人 |
DANIEL FRESHE,FR;LYUSEN NEDELEK,FR;GI PLASSAR,FR;NEIL LESLI BRAUN,GB |
分类号 |
C07D487/04;A61K31/55;A61P9/08;A61P9/12;C07D487/06 |
主分类号 |
C07D487/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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