A CONJUGATE OF BIOMACROMOLECULE WITH BIOREDUCTIVE AND PREPARATIVE METHOD THEREOF

摘要

Conjugate of biomacromolecule with bioreductive which can be useful for treating tumor is provided.The biomacromolecule is selected from transferrin comprising Fe, Ru, Ga or Pt, somatostatin, EPG, folacin acid or transcobalamin, and the bioreductive is selected from quinones, aromatic nitrogen oxides, fatty nitrogen oxides, heterocyclic nitro compound, transition metal compound. Such conjugate can selectly target the tumor cells, and low the toxity of medicines and survivability of tumor cells, so the conjugate can be used for delivery anti-tumor compounds or treating tumor.