发明名称 |
FREMGANGSMAADE TIL FREMSTILLING AF 2-ARYLPRPIONSYRER, MIKROORGANISMER OG ENZYMER ANVENDELIGE VED FREMGANGSMAADEN, OG FARMACEUTISKE KOMPOSITIONER INDEHOLDENDE FORBINDELSERNE |
摘要 |
A process for the preparation of a pharmaceutically active compound in a stereospecific form of the formula <CHEM> or a pharmaceutically acceptable salt or ester thereof, like an alkali metal salt or an alkaline earth metal salt or a pivaloyl ester, wherein R1 represents an optionally substituted aryl group such as a phenyl or naphthyl group optionally included in a heterocyclic ring system, which is optionally substituted, or represents a heteroaromatic ring system containing in addition to carbon atoms one or more atoms selected from nitrogen, sulphur and oxygen, this ring system being optionally substituted, which comprises subjecting a compound of the formula <CHEM> wherein R2 is an ester residue and preferably an alkyl group optionally substituted, to the action of a micro-organism having the ability for stereoselective hydrolysis of compound (II) into compound (I), having at least 80% by weight the S-configuration, and if desired converting compound (I) into the pharmaceutically acceptable salt or ester thereof. |
申请公布号 |
DK4987(D0) |
申请公布日期 |
1987.01.06 |
申请号 |
DK19870000049 |
申请日期 |
1987.01.06 |
申请人 |
GIST-BROCADES NV;SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. |
发明人 |
BERTOLA, MAURO ATTILIO;MARX, ARTHUR FRIEDRICH;KOGER, HEIN SIMON;QUAX, WILHELMUS JOHANNES;VAN DER LAKEN, CORNELIS JAVOBUS;PHILLIPS, GARETH THOMAS;ROBERTSON, BRIAN WILLIAM;WATTS, PETER DOUGLAS |
分类号 |
C12N15/09;A61K31/19;A61K31/33;A61P25/04;A61P29/00;C07C57/30;C07D209/46;C07H21/04;C12N1/20;C12N1/21;C12N9/18;C12N15/00;C12P7/40;C12P17/00;C12P41/00;C12R1/06;C12R1/10;C12R1/125;C12R1/19;C12R1/38;C12R1/385;C12R1/39;C12R1/40;C12R1/465;C12R1/785;(IPC1-7):C12P7/40;C07C59/64 |
主分类号 |
C12N15/09 |
代理机构 |
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