| 摘要 |
PURPOSE:To industrially and advantageously produce D-pantoic acid capable of making D-pantolactone which is an important synthetic intermediate for pantothenic acid, CoA, etc., by reducing ketopantoic acid or/and a salt thereof with a microorganism. CONSTITUTION:Ketopantoic acid or a salt thereof or both are reduced with at least one microorganism selected from microorganisms belonging to the genuses Nocardia, Rhodococcus, Nocardioides, Mycobacterium, Strepto sporangium and Streptomyces. The microorganism is previously cultivated and the cultivated microbial cells are added to a substrate solution at 6-10 pH. The supernatant after removing the microbial cells is then acidified and heated to cyclize ketopantoic acid and pantoic acid into ketopantolactone and pantolactone respectively. |
