| 摘要 |
PURPOSE:To obtain the titled tissue utilizable as an excellent bioreactor or biosensor, etc., by spinning an aqueous solution of a substance containing a specific active protein, etc., into a coagulation bath, thereby immobilizing the active protein. CONSTITUTION:An active protein (e.g. transferase) or a substance containing the active protein is dissolved or suspended in an aqueous solution of a water-soluble alginate (e.g. sodium alginate) or a mixed aqueous solution of an alginate and an acidic polysaccharide (e.g. pectin) and/or a water-soluble protein (e.g. gelatin), and the dispersion or solution is extruded into a coagulation bath composed of an inorganic salt or organic salt of a polyvalent metal ion (e.g. Ca) through a nozzle having an equivalent diameter of <=0.5mm at an extrusion rate of 0.5-100m/min to effect the immobilization of the active protein in the form of fiber. The obtained alginic acid fiber having a diameter of <=0.5mm and aspect ratio (length/diameter ratio) of <=150 is formed in the form of paper. The paper is dried at <=70 deg.C under tension to obtain the objective fiber paper. |
