Antibodies to receptor of advanced glycation end products (RAGE) and uses thereof

摘要

The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example missfolded proteins like amyloid β and advanced glycation-end-products.

主权项

1. An isolated monoclonal antibody or antigen-binding fragment thereof comprising an antigen binding domain, said antibody or antigen-binding fragment capable of binding an epitope of a human RAGE molecule, said antigen binding domain comprising:
three heavy chain variable region CDRs having the sequences SEQ ID NO: 2, SEQ ID NO: 3, and SEQ ID NO: 4, and three light chain variable region CDRs having the sequences SEQ ID NO: 6, SEQ ID NO: 7, and SEQ ID NO: 8.