发明名称 Antihelmintic macrocyclic lactones and their production by fermentation.
摘要 <p>A novel microorganism ATCC-53110 is formed by the protoplast fusion of strains of Streptomyces avermitilis and Streptomyces hygroscopicus. A novel macrolide is isolated from the fermentation broth of this microorganism. The structure of the novel compounds isolated from the microorganism is presented based upon analytical studies. The compounds are highly potent antiparasitic, insecticidal, and anthelmintic agents, and may be made into suitable compositions for pharmaceutical, veterinary and agricultural use. The compounds have the formula: &lt;CHEM&gt; in which R1, R2, R3 and R4 are defined as follows: &lt;TABLE&gt; </p>
申请公布号 EP0205251(A1) 申请公布日期 1986.12.17
申请号 EP19860303294 申请日期 1986.04.30
申请人 MERCK & CO. INC. 发明人 GOEGELMAN, ROBERT T.
分类号 C07D493/20;A01N43/90;A61K31/365;A61P33/10;C07H19/01;C12N15/02;C12P17/18;C12R1/465;(IPC1-7):C07D493/22;C12P19/62;A61K31/65;A01N43/24 主分类号 C07D493/20
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