发明名称 WERKWIJZE VOOR HET BEREIDEN VAN AMINOALCOHOLVERBINDINGEN ALSMEDE WERKWIJZE VOOR HET BEREIDEN VAN FARMACOLOGISCHE PREPARATEN MET TEN MINSTE EEN DERGELIJKE AMINOALCOHOLVERBINDING ALS WERKZAME STOF.
摘要 Aminoalcohol derivatives corresponding to the formula (I) <IMAGE> in which Q is a group <IMAGE> and the other substituents have the meaning shown in Claim 1 are prepared by reaction with a compound of formula I, in which Q represents a group <IMAGE> or <IMAGE>, with an amine of type R3R4NH, Z being a halogen. The alcohol can then be esterified by reaction with an acid or an anhydride as defined in Claim 1. The compounds obtained have activities on the cardiovascular system, for example antihypertensive and/or antispasmodic activities, peripheral vasodilative activity, protective activity against myocardial anoxia, hypolipidemiating activity, antithrombotic activity, beta -lytic activity or platelet aggregation inhibiting activity, and/or activity on the central nervous system, for example a tranquillising activity.
申请公布号 NL180936(B) 申请公布日期 1986.12.16
申请号 NL19760012794 申请日期 1976.11.17
申请人 CONTINENTAL PHARMA, INC. TE BRUSSEL, BELGIE. 发明人
分类号 A61K31/13;A61K31/135;A61K31/195;A61K31/215;A61K31/22;A61K31/335;A61K31/38;A61K31/381;A61K31/382;A61K31/395;A61K31/435;A61K31/495;A61K31/535;A61K31/54;A61P3/06;A61P9/00;A61P9/08;A61P9/12;A61P25/26;B01J23/00;B01J25/00;B01J27/00;B01J31/00;C07B61/00;C07C67/00;C07C213/00;C07C215/38;C07C217/56;C07C219/22;C07C225/16;C07C233/43;C07C233/73;C07C233/78;C07C255/24;C07C255/30;C07C255/58;C07C271/16;C07C311/01;C07C313/00;C07C323/25;C07C323/27;C07C323/32;C07C323/33;C07C323/41;C07C323/49;C07C323/62;C07D209/08;C07D211/14;C07D215/06;C07D223/16;C07D265/30;C07D265/36;C07D277/60;C07D279/08;C07D281/10;C07D307/79;C07D311/04;C07D313/08;C07D327/00;C07D327/06;C07D333/54;C07D335/06;C07D337/06;C07D337/08;C07D339/00;C07D339/06;C07D339/08;C07D401/10;C07D401/12;C07D403/10;C07D405/06;C07D409/06;C07D409/12 主分类号 A61K31/13
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