摘要 |
PURPOSE:An antitumor agent, containing a specific diterpene which is a pisiferic acid derivative as an acetive constituent and capable of exhibiting improved inhibitory action on cell multiplication for Hela cells. CONSTITUTION:An antitumor agent containing a diterpene expressed by the formula (X is hydroxymethyl, formyl, alkyl, etc.; Y is OH or acyloxy, provided that Y represents acyloxy when X is carboxyl) as an active constituent. The compound expressed by the formula exhibits improved inhibitory action on cell multiplication for Hela cells (cellular strain separated from human cervical cancer tissues). The administration is carried out by the method of intravenous injection, subcutaneous injection, oral capsule, etc. and the dose thereof is within 5-100mg/kg range for the injection and 20-500mg/kg range for the oral agent.
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