发明名称 QUINOLONECARBOXYLIC ACID DERIVATIVE
摘要 NEW MATERIAL:A compound shown by the formula I (R and R<1> are H or lower alkyl; R<2> is R, R<1>, p-nitrobenzyl or p-aminobenzyl; Y is H or halogen), its hydrate and its salt. EXAMPLE:1-Cyclopropyl-7-(3-ethylaminomethyl-1-pyrrolidinyl)-6,8-difluo ro-1,4 dihydro-4-oxo-3-quinolonecarboxylic acid hydrochloride. USE:An antibacterial agent. Showing improved antibacterial activity, having improved absorption in animals, improved transition to tissue, improved stability and acceptability. PREPARATION:For example, a compound shown by the formula II (X is halogen) is condensed with a compound shown by the formula III in the absence of a solvent or in a polar solvent such as anhydrous acetonitrile, etc., in the presence of a deoxidizer such as diazabicyclo [5,4,0]-7-undecene, etc., at room temperature-200 deg.C to give a compound shown by the formula I.
申请公布号 JPS61267573(A) 申请公布日期 1986.11.27
申请号 JP19850252005 申请日期 1985.11.12
申请人 KYORIN PHARMACEUT CO LTD 发明人 IRIKURA TSUTOMU;SUZUE SEIGO;HIRAI KEIJI;ISHIZAKI TAKAYOSHI
分类号 A61K31/47;A61P31/04;C07C63/70;C07D215/56;C07D401/04 主分类号 A61K31/47
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