发明名称 1,3-DITHIOL DERIVATIVE
摘要 NEW MATERIAL:A compound expressed by formula I (R<1> and R<2> are alkyl, cycloalkyl, lower alkenyl, lower alkynyl, aryl or aralkyl and both may be substituted by cyano, lower alkoxy, lower alkylthio, lower alkoxycarbonyl, etc., provided that R<1> and R<2> are not CH3 or C2H5 at the same time; Q is acid residue). EXAMPLE:N-(1, 3-dithiol-2-ylidene)-N-methyl-N-ethoxycarbonylmethylammonium perchlorate. USE:A medicine and remedy for hepatopathy, capable of exhibiting better remedial activity than malotilate expressed by formula II, and being an original hepatic function restorative agent or hepatic function stimulant for the reduction in substantial number of cells and function or the liver causing necrosis involving them, etc. PREPARATION:A dithiolium salt expressed by formula III (R is lower alkyl or aralkyl) is reacted with an amine expressed by formula IV in an inert solvent at -20 deg.C-the boiling point of the solvent to afford the aimed compound expressed by formula I.
申请公布号 JPS61267572(A) 申请公布日期 1986.11.27
申请号 JP19850290830 申请日期 1985.12.25
申请人 BANYU PHARMACEUT CO LTD 发明人 YANO MITSUO;TSUCHIYA YOSHIMI;HIRAYAMA YUKIO;NAKAMICHI KYOKO;YOSHIZAWA JUNJI
分类号 A61K31/385;A61P1/16;C07D339/06;C07D409/04;C07D413/04;C07D417/04 主分类号 A61K31/385
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