| 摘要 |
<p>2-(2-Hydroxy ethoxy)ethyl N-(a,a,a-trifluoro m-tolyl) anthranilate for pharmacological use as anti-inflammatory and analgesic, is made by (a) reaction of an alkali, pref. K, salt of N-(a,a,a-trifluoro m-tolyl) anthranilic acid with 2-(2-chloro ethoxy) ethanol in aq. medium at reflux temp.; (b) extraction of the anthranilate obtained with an organic solvent e.g. ethyl acetate, ether or benzene; (c) removal of the solvent by evaporation under reduced pressure; (d) soln. of the prod. in methanol; and (e) sepn. of the anthranilate by high resolution liquid chromatography.</p> |
