发明名称 |
Oxygen analogs of cephalosporins |
摘要 |
In accordance with this invention, it has been found that the oxygen analog of 7-amino-cephalosporanic acid and biologically active derivatives thereof can be formed from esters of 7-amino-cephalosporanic acid. Esters of 7-oxocephalosporanic acid can be formed by diazotization of an ester or 7-amino-cephalosporanic acid and contact of the diazo compound so formed with a hypohalous acid and a base in a water miscible organic solvent. Oxygen analogs of 7-aminocephalosporins isolated as esters are then formed by reducing the aforesaid ester to the corresponding 7 beta -hydroxy-cephalosporanate and then forming the desired analog by introduction of a side chain via hydroxyl group modification. Oxygen analogs of 7-amino-cephalosporins are then formed by regeneration of the acid via protective group removal.
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申请公布号 |
US4622394(A) |
申请公布日期 |
1986.11.11 |
申请号 |
US19770856749 |
申请日期 |
1977.12.02 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
SHEEHAN, JOHN C.;LO, YOUNG S. |
分类号 |
C07D501/00;(IPC1-7):C07D501/00;A61K31/545 |
主分类号 |
C07D501/00 |
代理机构 |
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地址 |
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