PROCESS FOR THE PREPARING OF NEOCARZYNOSTATIN DERIVATIVES

摘要

Neocarzinostatin (I) derivs., (SMA)-(NCS)-(SMA) (A: NCS = divalent one residue in which an H has been removed from each of the 1 amino gp. of the A/a residue at the N-termina of I and of the 1 amino gp. of the Lys residue at the 20 th position from the N-terminal of I; SMA=monovalent partially esterified styrenemaleic anhydride copolymer residue having an average mol. wt. of 800-2500) were prepd. by treating aq. I with at least 2-fold excess partially esterifed styrene-maleic anhydride copolymer in powder form and subjecting the reaction mixt. to gel filtration to isolate A. The product, based on the growth in hibitor of sarcina lutea, is 1.34 times more effective in anticancer activity than I.