| 摘要 |
Compounds of general formula (I) wherein: R1 and R2 are independently hydrogen, C1-6 alkyl or together are a group X which is C3-6 polymethylene optionally interrupted by O, S or NR6 wherein R6 is hydrogen or C1-6 alkyl; R3 is phenyl, optionally substituted by one or more substituents selected from halogen, CF3, nitro, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C2-7 alkanoyl, carboxyl, C1-6 alkoxycarbonyl, cyano, CONR7R8 wherein R7 and R8 are selected from hydrogen or C1-6 alkyl or together are a group X; NR9 R10 wherein R9 and R10 are selected from hydrogen, C1-6 alkyl, C2-7 alkanoyl or C1-6 alkylsulphonyl or together are a group X; SO2NR11R12 wherein R11 and R12 are selected from hydrogen or C1-6 alkyl or together are a group X; or S(O)mR13 wherein m is 1 or 2 and R13 is C1-6 alkyl; R4 and R5 are independently selected from hydrogen, C1-6 alkyl, cyano, amino, aminocarbonyl, or aminocarbamoyl optionally substituted by one or two C1-6 alkyl groups or together are a group X, halogen, CF3, nitro, C1-6 alkoxy, C1-6 alkylthio, C2-7 alkanoyloxy or hydroxy, or together are methylenedioxy or C3-5 polymethylene; are of value in the prophylaxis and treatment of allergic and inflammatory disorders. |
