Hydrogels with increased organic solvent soluble active agent loading capacity, their preparation and the use thereof.

摘要

An organic solvent active agent containing water-insoluble hydrophilic hydrogel comprising a copolymer of (A) a water-soluble monoolefinic monomer or a mixture thereof optionally containing up to 50 % thereof of one or more water-insoluble monoolefinic monomers and (B) a terminally diolefinic hydrophobic macromer containing polypropylene oxide or polytetramethylene oxide units prepared in the presence of an effective macromer expanding amount of a macromer soluble compound of the formula R min &lparstr& R sec -O &rparstr& nR sec min where R min , R sec , R sec min and n are as defined in the claims, hydrogels useful in the loading of such active agents, their preparation, and use are disclosed.